Professor & Head of Inst of Aquaculture
Institute of Aquaculture Pathfoot Building, University of Stirling, Stirling, FK9 4LA
My interests lie in fish health integrating behaviour, immunity and bioinformatics toward improving health in aquaculture. I approach this with an integrative suite of methods both experimental and theoretical spanning across the fields of behavioural ecology, evolution and immunity. This is underpinned by the application of state of the art -omics techniques including proteomics, transcriptome and microbiome and WGS supported within a proven bioinformatic strategy for assembly, annotation, analysis and network modelling. Throughout my career to date my major academic interest has become to explore how immunity has evolved and recently how environmental conditions, particularly temperature, modulate the plasticity of the immune response.
AQUASoS; an integrative scalable interdisciplinary approach for climate resilient sustainable aquaculture
PI: Professor Simon MacKenzie
Funded by: Biotechnology and Biological Sciences Research Council
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Effect of swimming training in smolt; A Basic Study
PI: Professor Amaya Albalat
Funded by: The Research Council of Norway
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Vaccines against AMR in Aquaculture
PI: Professor Margaret Crumlish
Funded by: International Development Research Centre
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ROBUST-SMOLT Impact of Early Life History in Freshwater Recirculation Aquaculture Systems on A. Salmon Robustness and Susceptibility to Disease at Sea
PI: Professor Herve Migaud
Funded by: Biotechnology and Biological Sciences Research Council
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Impact of Net Cleaning and Sea Lice treatment upon Gill Health in Salmon
PI: Professor Simon MacKenzie
Funded by: The Norwegian Seafood Research Fund
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Development of a full season production protocol for rainbow trout
PI: Professor Simon MacKenzie
Funded by: Norwegian Research Council
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Technical considerations of closed containment sea pen production for some life stages of salmonids
PI:
Funded by: Scottish Aquaculture Research Forum
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Health and welfare of lumpfish in hatchery production and deployed in Scottish salmon cages
PI: Professor Sonia Rey Planellas
Funded by: Scottish Aquaculture Innovation Centre
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Article
Elsheshtawy A, Clokie BGJ, Albalat A, Nylund A, Kvåle BL, Andersen L, Moore LJ & MacKenzie S (2024) Exploring the impact of thermal delousing on gill health and microbiome dynamics in farmed Atlantic Salmon. Aquaculture, 582, Art. No.: 740455. https://doi.org/10.1016/j.aquaculture.2023.740455
Article
Molto-Martin I, Neil DM, Coates CJ, MacKenzie SA, Bass D, Stentiford GD & Albalat A (2024) Infection of Norway lobster (Nephrops norvegicus) by the parasite Hematodinium sp.: insights from 30 years of field observations. Royal Society Open Science, 11 (1). https://doi.org/10.1098/rsos.231147
Article
Net cleaning impacts Atlantic salmon gill health through microbiome dysbiosis
Elsheshtawy A, Clokie BGJ, Albalat A, Nylund A, Isaksen TE, Napsøy Indrebø E, Andersen L, Moore LJ & MacKenzie S (2023) Net cleaning impacts Atlantic salmon gill health through microbiome dysbiosis. Frontiers in Aquaculture, 2. https://doi.org/10.3389/faquc.2023.1125595
Article
Vera LM, de Alba G, Santos S, Szewczyk TM, Mackenzie SA, Sánchez-Vázquez FJ & Rey-Planellas S (2023) Circadian rhythm of preferred temperature in fish: Behavioural thermoregulation linked to daily photocycles in zebrafish and Nile tilapia. Journal of Thermal Biology, 113, Art. No.: 103544. https://doi.org/10.1016/j.jtherbio.2023.103544
Article
Clokie BGJ, Elsheshtawy A, Albalat A, Nylund A, Beveridge A, Payne CJ & MacKenzie S (2022) Optimization of Low-Biomass Sample Collection and Quantitative PCR-Based Titration Impact 16S rRNA Microbiome Resolution. Microbiology Spectrum, 10 (6), Art. No.: e02255-22. https://doi.org/10.1128/spectrum.02255-22
Article
Payne C, Turnbull J, MacKenzie S & Crumlish M (2022) The effect of oxytetracycline treatment on the gut microbiome community dynamics in rainbow trout (Oncorhynchus mykiss) over time. Aquaculture, 560, Art. No.: 738559. https://doi.org/10.1016/j.aquaculture.2022.738559
Article
Cui W, Takahashi E, Morro B, Balseiro P, Albalat A, Pedrosa C, Mackenzie S, Nilsen TO, Sveier H, Ebbesson LO, Handeland SO & Shimizu M (2022) Changes in circulating insulin-like growth factor-1 and its binding proteins in yearling rainbow trout during spring under natural and manipulated photoperiods and their relationships with gill Na+, K+-ATPase and body size. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 268, Art. No.: 111205. https://doi.org/10.1016/j.cbpa.2022.111205
Article
Rey S, Jin X, Damsgård B, Bégout M & Mackenzie S (2021) Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour. BMC Genomics, 22 (1), Art. No.: 33. https://doi.org/10.1186/s12864-020-07317-z
Article
Stressor controllability modulates the stress response in fish
Cerqueira M, Millot S, Silva T, Félix AS, Castanheira MF, Rey S, MacKenzie S, Oliveira GA, Oliveira CCV & Oliveira RF (2021) Stressor controllability modulates the stress response in fish. BMC Neuroscience, 22 (1), Art. No.: 48. https://doi.org/10.1186/s12868-021-00653-0
Article
Morro B, Broughton R, Balseiro P, Handeland SO, Mackenzie S, Doherty MK, Whitfield PD, Shimizu M, Gorissen M, Sveier H & Albalat A (2021) Endoplasmic reticulum stress as a key mechanism in stunted growth of seawater rainbow trout (Oncorhynchus mykiss). BMC Genomics, 22 (1), Art. No.: 824. https://doi.org/10.1186/s12864-021-08153-5
Article
Elsheshtawy A, Clokie BGJ, Albalat A, Beveridge A, Hamza A, Ibrahim A & MacKenzie S (2021) Characterization of External Mucosal Microbiomes of Nile Tilapia and Grey Mullet Co-cultured in Semi-Intensive Pond Systems. Frontiers in Microbiology, 12, Art. No.: 773860. https://doi.org/10.3389/fmicb.2021.773860
Article
McGowan M, MacKenzie S, Steiropoulos N & Weidmann M (2021) Testing of NKA expression by mobile real time PCR is an efficient indicator of smoltification status of farmed Atlantic salmon. Aquaculture, 544, Art. No.: 737085. https://doi.org/10.1016/j.aquaculture.2021.737085
Article
Payne CJ, Turnbull JF, MacKenzie S & Crumlish M (2021) Investigating the Effect of an Oxytetracycline Treatment on the Gut Microbiome and Antimicrobial Resistance Gene Dynamics in Nile Tilapia (Oreochromis niloticus). Antibiotics, 10 (10), Art. No.: 1213. https://doi.org/10.3390/antibiotics10101213
Article
McKenzie DJ, Palstra AP, Planas J, MacKenzie S, Bégout M, Thorarensen H, Vandeputte M, Mes D, Rey S, De Boeck G, Domenici P & Skov PV (2021) Aerobic swimming in intensive finfish aquaculture: applications for production, mitigation and selection. Reviews in Aquaculture, 13 (1), pp. 138-155. https://doi.org/10.1111/raq.12467
Article
Mandal SC, Weidmann M, Albalat A, Carrick E, Morro B & MacKenzie S (2020) Polarized trout epithelial cells regulate transepithelial electrical resistance, gene expression, and the phosphoproteome in response to viral infection. Frontiers in Immunology, 11, Art. No.: 1809. https://doi.org/10.3389/fimmu.2020.01809
Article
Jin X, Morro B, Tørresen OK, Moiche V, Solbakken MH, Jakobsen KS, Jentoft S & MacKenzie S (2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System. Frontiers in Immunology, 11, Art. No.: 609456. https://doi.org/10.3389/fimmu.2020.609456
Article
Glencross BD, Baily J, Berntssen MHG, Hardy R, MacKenzie S & Tocher DR (2020) Risk assessment of the use of alternative animal and plant raw material resources in aquaculture feeds. Reviews in Aquaculture, 12 (2), pp. 703-758. https://doi.org/10.1111/raq.12347
Article
Morro B, Balseiro P, Albalat A, MacKenzie S, Pedrosa C, Nilsen TO, Suzuki S, Shimizu M, Sveier H, Gorissen M, Ebbesson LOE & Handeland SO (2020) Effects of temperature and photoperiod on rainbow trout (Oncorhynchus mykiss) smoltification and haematopoiesis. Aquaculture, 519, Art. No.: 734711. https://doi.org/10.1016/j.aquaculture.2019.734711
Article
Cerqueira M, Millot S, Felix A, Silva T, Oliveira GA, Oliveira CCV, Rey S, MacKenzie S & Oliveira R (2020) Cognitive appraisal in fish: stressor predictability modulates the physiological and neurobehavioural stress response in sea bass. Proceedings of the Royal Society B: Biological Sciences, 287 (1923), Art. No.: 20192922. https://doi.org/10.1098/rspb.2019.2922
Article
Ferrari S, Rey S, Høglund E, Øverli Ø, Chatain B, MacKenzie S & Bégout M (2020) Physiological responses during acute stress recovery depend on stress coping style in European sea bass, Dicentrarchus labrax. Physiology & Behavior, 216, Art. No.: 112801. https://doi.org/10.1016/j.physbeh.2020.112801
Article
Mycotoxins in aquaculture: feed and food
Gonçalves RA, Schatzmayr D, Albalat A & Mackenzie S (2020) Mycotoxins in aquaculture: feed and food. Reviews in Aquaculture, 12 (1), pp. 145-175. https://doi.org/10.1111/raq.12310
Article
Morro B, Doherty MK, Balseiro P, Handeland SO, MacKenzie S, Sveier H & Albalat A (2020) Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss). PLOS ONE, 15 (1), Art. No.: e0227003. https://doi.org/10.1371/journal.pone.0227003
Article
Fatsini E, Rey S, Ibarra-Zatarain Z, Boltaña S, Mackenzie S & Duncan NJ (2020) Linking stress coping styles with brain mRNA abundance of selected transcripts for Senegalese sole (Solea senegalensis) juveniles. Physiology and Behavior, 213, Art. No.: 112724. https://doi.org/10.1016/j.physbeh.2019.112724
Presentation / Talk
Using thermal choices as indicators for fish welfare
Rey Planellas S, MacKenzie S & Huntingford F (2019) Using thermal choices as indicators for fish welfare. ISAE 2019, Bergen, 05.08.2019-09.08.2019.
Article
Ribas L, Crespo B, Sanchez-Baizan N, Xavier D, Kuhl H, Rodriguez JM, Diaz N, Boltana S, MacKenzie S, Moran F, Zanuy S, Gomez A & Piferrer F (2019) Characterization of the European Sea Bass (Dicentrarchus labrax) Gonadal Transcriptome During Sexual Development. Marine Biotechnology, 21 (3), pp. 359-373. https://doi.org/10.1007/s10126-019-09886-x
Article
Morro B, Balseiro P, Albalat a, Pedrosa C, Mackenzie S, Nakamura S, Shimizu M, Nilsen TO, Sveier H, Ebbesson LO & Handeland SO (2019) Effects of different photoperiod regimes on the smoltification and seawater adaptation of seawater-farmed rainbow trout (Oncorhynchus mykiss): Insights from Na+, K+-ATPase activity and transcription of osmoregulation and growth regulation genes. Aquaculture, 507, pp. 282-292. https://doi.org/10.1016/j.aquaculture.2019.04.039
Article
Effects of deoxynivalenol exposure time and contamination levels on rainbow trout
Gonçalves RA, Menanteau-Ledouble S, Schöller M, Eder A, Schmidt-Posthaus H, MacKenzie S & El-Matbouli M (2019) Effects of deoxynivalenol exposure time and contamination levels on rainbow trout. Journal of the World Aquaculture Society, 50 (1), pp. 137-154. https://doi.org/10.1111/jwas.12542
Newspaper / Magazine
What zebrafish reveal about importance of looks vs personality in choosing a mate
Rey Planellas S & MacKenzie S (2018) What zebrafish reveal about importance of looks vs personality in choosing a mate. The Conversation. 21.09.2018.
Article
Vargas R, Mackenzie S & Rey S (2018) 'Love at first sight': The effect of personality and colouration patterns in the reproductive success of zebrafish (Danio rerio). PLOS ONE, 13 (9), Art. No.: e0203320. https://doi.org/10.1371/journal.pone.0203320
Article
Torrealba D, Balasch JC, Criado M, Tort L, MacKenzie S & Roher N (2018) Functional evidence for the inflammatory reflex in teleosts: A novel alpha7 nicotinic acetylcholine receptor modulates the macrophage response to dsRNA. Developmental and Comparative Immunology, 84, pp. 279-291. https://doi.org/10.1016/j.dci.2018.02.020
Article
Boltana S, Sanhueza N, Donoso A, Aguilar A, Crespo D, Vergara D, Arriagada G, Morales-Lange B, Mercado L, Rey S, Tort L & MacKenzie S (2018) The expression of TRPV channels, prostaglandin E2 and pro-inflammatory cytokines during behavioural fever in fish. Brain, Behavior, and Immunity, 71, pp. 169-181. https://doi.org/10.1016/j.bbi.2018.03.023
Article
Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish
Boltana S, Aguilar A, Sanhueza N, Donoso A, Mercado L, Imarai M & Mackenzie S (2018) Behavioral Fever Drives Epigenetic Modulation of the Immune Response in Fish. Frontiers in Immunology, 9, Art. No.: 1241. https://doi.org/10.3389/fimmu.2018.01241
Conference Paper (published)
Rey Planellas S, Mackenzie S & Planas J (2018) Assessing the Influence of Individual Variation in Coping Styles on Swimming Performance in Zebrafish (Danio Rerio) [Swimming performance in zebrafish]. In: FitFish Annual Conference 2016. FITFISH EU cost action, Belgrade, Serbia, 22.04.2016-22.04.2016. FitFish, p. 34. https://www.fitfish.eu/upload_mm/c/5/8/bc3a7541-dd20-4aa4-bbe4-f074612af4cb_FITFISH%20annual%20conference%202016.pdf
Article
Goncalves RA, Navarro-Guillen C, Gilannejad N, Dias J, Schatzmayr D, Bichl G, Czabany T, Moyano FJ, Rema P, Yufera M, MacKenzie S & Martinez-Rodriguez G (2018) Impact of deoxynivalenol on rainbow trout: Growth performance, digestibility, key gene expression regulation and metabolism. Aquaculture, 490, pp. 362-372. https://doi.org/10.1016/j.aquaculture.2018.03.001
Article
Fatsini E, Rey S, Ibarra-Zatarain Z, MacKenzie S & Duncan N (2017) Dominance behaviour in a non-aggressive flatfish, Senegalese sole (Solea senegalensis) and brain mRNA abundance of selected transcripts. PLoS ONE, 12 (9), Art. No.: e0184283. https://doi.org/10.1371/journal.pone.0184283
Article
Boltana S, Castellana B, Goetz G, Tort L, Teles M, Mulero V, Novoa B, Figueras A, Goetz FW, Gallardo-Escarate C, Planas JV & MacKenzie S (2017) Extending immunological profiling in the gilthead sea bream, sparus aurata, by enriched cDNA library analysis, microarray design and initial studies upon the inflammatory response to PAMPs. International Journal of Molecular Sciences, 18 (2), Art. No.: 317. https://doi.org/10.3390/ijms18020317
Article
Behavioural fever in zebrafish larvae
Rey S, Moiche Vega AV, Boltana S, Teles M & MacKenzie S (2017) Behavioural fever in zebrafish larvae. Developmental and Comparative Immunology, 67, pp. 287-292. https://doi.org/10.1016/j.dci.2016.09.008
Commentary
Stress induced hyperthermia in zebrafish: a reply to Key et al.
Rey S, Huntingford FA, Knowles TG & MacKenzie S (2017) Stress induced hyperthermia in zebrafish: a reply to Key et al.. Commentary on: Key B et al. 2017 Problems with equating thermal preference with ‘emotional fever’ and sentience: comment on ‘Fish can show emotional fever: stress-induced hyperthermia in zebrafish’ by Rey et al. (2015). Proc. R. Soc. B 284, 20160681. (doi:10.1098/rspb.2016.0681). Proceedings of the Royal Society B: Biological Sciences, 284 (1847), Art. No.: 20162124. https://doi.org/10.1098/rspb.2016.2124
Article
Boltana S, Valenzuela-Miranda D, Aguilar A, MacKenzie S & Gallardo-Escarate C (2016) Long noncoding RNAs (lncRNAs) dynamics evidence immunomodulation during ISAV-Infected Atlantic salmon (Salmo salar). Scientific Reports, 6 (4), Art. No.: 22698. https://doi.org/10.1038/srep22698
Article
Iron and Fur in the life cycle of the zoonotic pathogen Vibrio vulnificus
Pajuelo D, Hernandez-Cabanyero C, Sanjuan E, Lee C, Silva-Hernandez FX, Hor L, MacKenzie S & Amaro C (2016) Iron and Fur in the life cycle of the zoonotic pathogen Vibrio vulnificus. Environmental Microbiology, 18 (11), pp. 4005-4022. https://doi.org/10.1111/1462-2920.13424
Article
Thermal preference predicts animal personality in Nile tilapia Oreochromis niloticus
Cerqueira M, Rey S, Featherstone Z, Crumlish M & MacKenzie S (2016) Thermal preference predicts animal personality in Nile tilapia Oreochromis niloticus. Journal of Animal Ecology, 85 (5), pp. 1389-1400. https://doi.org/10.1111/1365-2656.12555
Article
The response of fish to immunostimulant diets
Vallejos-Vidal E, Reyes-López F, Teles M & MacKenzie S (2016) The response of fish to immunostimulant diets. Fish and Shellfish Immunology, 56, pp. 34-69. https://doi.org/10.1016/j.fsi.2016.06.028
Book Chapter
Torresen OK, Rise ML, Jin X, Star B, MacKenzie S, Jakobsen KS, Nederbragt AJ & Jentoft S (2016) An improved version of the Atlantic cod genome and advancements in functional genomics: implications for the future of cod farming. In: MacKenzie S & Jentoft S (eds.) Genomics in aquaculture. Cambridge, MA, USA: Elsevier, pp. 45-72. http://store.elsevier.com/Genomics-in-Aquaculture/isbn-9780128014189/
Edited Book
MacKenzie S & Jentoft S (eds.) (2016) Genomics in Aquaculture. Cambridge, MA, USA: Academic Press. http://store.elsevier.com/Genomics-in-Aquaculture/isbn-9780128014189/
Article
Rey S, Ribas L, Capdevila DM, Callol A, Huntingford FA, Pilarczyk M, Kadri S & MacKenzie S (2016) Differential responses to environmental challenge by common carp Cyprinus carpio highlight the importance of coping style in integrative physiology. Journal of Fish Biology, 88 (3), pp. 1056-1069. https://doi.org/10.1111/jfb.12877
Article
Reyes-Lopez F, Romeo JS, Vallejos-Vidal E, Reyes-Cerpa S, Sandino AM, Tort L, MacKenzie S & Imarai M (2015) Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV). Developmental and Comparative Immunology, 53 (1), pp. 210-221. https://doi.org/10.1016/j.dci.2015.06.017
Article
Jensen L, Boltana S, Obach A, McGurk C, Waagbo R & MacKenzie S (2015) Investigating the underlying mechanisms of temperature-related skin diseases in Atlantic salmon, Salmo salar L., as measured by quantitative histology, skin transcriptomics and composition. Journal of Fish Diseases, 38 (11), pp. 977-992. https://doi.org/10.1111/jfd.12314
Article
Fish can show emotional fever: stress-induced hyperthermia in zebrafish
Rey S, Huntingford FA, Boltaña S, Vargas R, Knowles TG & MacKenzie S (2015) Fish can show emotional fever: stress-induced hyperthermia in zebrafish. Proceedings of the Royal Society B: Biological Sciences, 282 (1819), Art. No.: 20152266. https://doi.org/10.1098/rspb.2015.2266
Article
Callol A, Reyes-Lopez F, Roig FJ, Goetz G, Goetz FW, Amaro C & MacKenzie S (2015) An enriched European eel transcriptome sheds light upon host-pathogen interactions with Vibrio vulnificus. PLoS ONE, 10 (7), Art. No.: e0133328. https://doi.org/10.1371/journal.pone.0133328
Article
Animal Personality Relates to Thermal Preference in Wild-Type Zebrafish, Danio rerio
Rey S, Digka N & MacKenzie S (2015) Animal Personality Relates to Thermal Preference in Wild-Type Zebrafish, Danio rerio. Zebrafish, 12 (3), pp. 243-249. https://doi.org/10.1089/zeb.2014.1076
Article
Callol A, Pajuelo D, Ebbesson L, Teles M, MacKenzie S & Amaro C (2015) Early steps in the European eel (Anguilla anguilla)-Vibrio vulnificus interaction in the gills: role of the RtxA13 toxin. Fish and Shellfish Immunology, 43 (2), pp. 502-509. https://doi.org/10.1016/j.fsi.2015.01.009
Article
Ruyra A, Torrealba D, Morera D, Tort L, MacKenzie S & Roher N (2015) Zebrafish liver (ZFL) cells are able to mount an anti-viral response after stimulation with Poly (I:C). Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 182, pp. 55-63. https://doi.org/10.1016/j.cbpb.2014.12.002
Article
Dios S, Balseiro P, Costa MM, Romero A, Boltana S, Roher N, MacKenzie S, Figueras A & Novoa B (2014) The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio). Zebrafish, 11 (5), pp. 421-433. https://doi.org/10.1089/zeb.2014.0995
Article
Garcia-Valtanen P, Ortega-Villaizan MdM, Martinez-Lopez A, Medina-Gali R, Perez L, MacKenzie S, Figueras A, Coll JM & Estepa A (2014) Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. Autophagy, 10 (9), pp. 1666-1680. https://doi.org/10.4161/auto.29557
Article
Boltana S, Tridico R, Teles M, MacKenzie S & Tort L (2014) Lipopolysaccharides isolated from Aeromonas salmonicida and Vibrio anguillarum show quantitative but not qualitative differences in inflammatory outcome in Sparus aurata (Gilthead seabream). Fish and Shellfish Immunology, 39 (2), pp. 475-482. https://doi.org/10.1016/j.fsi.2014.06.003
Article
Pereiro P, Dios S, Boltana S, Coll JM, Estepa A, MacKenzie S, Novoa B & Figueras A (2014) Transcriptome profiles associated to VHSV infection or DNA vaccination in turbot (Scophthalmus maximus). PLoS ONE, 9 (8), Art. No.: e104509. https://doi.org/10.1371/journal.pone.0104509
Article
Ruyra A, Cano-Sarabia M, Garcia-Valtanen P, Yero D, Gibert I, MacKenzie S, Estepa A, Maspoch D & Roher N (2014) Targeting and stimulation of the zebrafish (Danio rerio) innate immune system with LPS/dsRNA-loaded nanoliposomes. Vaccine, 32 (31), pp. 3955-3962. https://doi.org/10.1016/j.vaccine.2014.05.010
Article
Rey S, Boltana S, Vargas R, Roher N & MacKenzie S (2013) Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function. Molecular Ecology, 22 (24), pp. 6100-6115. https://doi.org/10.1111/mec.12556
Article
Callol A, Roher N, Amaro C & MacKenzie S (2013) Characterization of PAMP/PRR interactions in European eel (Anguillaanguilla) macrophage-like primary cell cultures. Fish and Shellfish Immunology, 35 (4), pp. 1216-1223. https://doi.org/10.1016/j.fsi.2013.07.037
Article
Ruyra A, Cano-Sarabia M, MacKenzie S, Maspoch D & Roher N (2013) A Novel Liposome-Based Nanocarrier Loaded with an LPS-dsRNA Cocktail for Fish Innate Immune System Stimulation. PLoS ONE, 8 (10), Art. No.: e76338. https://doi.org/10.1371/journal.pone.0076338
Article
Behavioural fever is a synergic signal amplifying the innate immune response
Boltana S, Rey S, Roher N, Vargas R, Huerta M, Huntingford FA, Goetz FW, Moore J, Garcia-Valtanen P, Estepa A & MacKenzie S (2013) Behavioural fever is a synergic signal amplifying the innate immune response. Proceedings of the Royal Society B: Biological Sciences, 280 (1766), Art. No.: 20131381. https://doi.org/10.1098/rspb.2013.1381
Article
Ferrer-Navarro M, Planell R, Yero D, Mongiardini E, Torrent G, Huedo P, Martinez P, Roher N, MacKenzie S, Gibert I & Daura X (2013) Abundance of the Quorum-Sensing Factor Ax21 in Four Strains of Stenotrophomonas maltophilia Correlates with Mortality Rate in a New Zebrafish Model of Infection. PLoS ONE, 8 (6), Art. No.: e67207. https://doi.org/10.1371/journal.pone.0067207
Article
Teles M, Boltana S, Reyes-Lopez F, Santos MA, MacKenzie S & Tort L (2013) Effects of Chronic Cortisol Administration on Global Expression of GR and the Liver Transcriptome in Sparus aurata. Marine Biotechnology, 15 (1), pp. 104-114. https://doi.org/10.1007/s10126-012-9467-y
Book Chapter
Developments in genomics relevant to disease control in aquaculture
MacKenzie S, Boltana S, Novoa B, Figueras A & Goetz FW (2012) Developments in genomics relevant to disease control in aquaculture. In: Austin B (ed.) Infectious Disease in Aquaculture: Prevention and Control. Woodhead Publishing Series in Food Science, Technology and Nutrition, 231. Cambridge: Woodhead Printing, pp. 331-352. http://www.sciencedirect.com/science/article/pii/B9780857090164500131; https://doi.org/10.1533/9780857095732.3.331
Article
Norambuena F, MacKenzie S, Bell JG, Callol A, Estevez A & Duncan N (2012) Prostaglandin (F and E, 2- and 3-series) production and cyclooxygenase (COX-2) gene expression of wild and cultured broodstock of senegalese sole (Solea senegalensis). General and Comparative Endocrinology, 177 (2), pp. 256-262. https://doi.org/10.1016/j.ygcen.2012.04.009
Article
Cepeda V, Cofre C, Gonzalez R, MacKenzie S & Vidal R (2012) Corrigendum to "Identification of genes involved in immune response of Atlantic salmon (Salmo salar) to IPN virus infection, using expressed sequence tags (EST) analysis" [Aquaculture 318 (2011) 54-60]. Aquaculture, 338-341, p. 314. https://doi.org/10.1016/j.aquaculture.2012.01.002
Article
Welfare of farmed fish in present and future production systems
Kiessling A, van de Vis H, Flik G & MacKenzie S (2012) Welfare of farmed fish in present and future production systems. Fish Physiology and Biochemistry, 38 (1), pp. 1-3. https://doi.org/10.1007/s10695-011-9594-9
Article
Crespo D, Mananos E, Roher N, MacKenzie S & Planas JV (2012) Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout. Biology of Reproduction, 86 (1), Art. No.: 5. https://doi.org/10.1095/biolreprod.111.094433
Book Chapter
Goetz FW, Planas JV, Diaz M, Iliev DB & MacKenzie S (2011) Culture of Fish Head Kidney Mononuclear Phagocytes and Muscle Satellite Cells: Valuable Models for Aquaculture Biotechnology Research. In: Fletcher G & Rise M (eds.) Aquaculture Biotechnology. Chichester: Wiley-Blackwell, pp. 207-221. http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0813810280.html; https://doi.org/10.1002/9780470963159.ch13
Article
PAMPs, PRRs and the genomics of gram negative bacterial recognition in fish
Boltana S, Roher N, Goetz FW & MacKenzie S (2011) PAMPs, PRRs and the genomics of gram negative bacterial recognition in fish. Developmental and Comparative Immunology, 35 (12), pp. 1195-1203. https://doi.org/10.1016/j.dci.2011.02.010
Article
RNA-Seq Reveals an Integrated Immune Response in Nucleated Erythrocytes
Morera D, Roher N, Ribas L, Balasch JC, Donate C, Callol A, Boltana S, Roberts S, Goetz G, Goetz FW & MacKenzie S (2011) RNA-Seq Reveals an Integrated Immune Response in Nucleated Erythrocytes. PLoS ONE, 6 (10), Art. No.: e26998. https://doi.org/10.1371/journal.pone.0026998
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Cepeda V, Cofre C, Gonzalez R, MacKenzie S & Vidal R (2011) Identification of genes involved in immune response of Atlantic salmon (Salmo salar) to IPN virus infection, using expressed sequence tag (EST) analysis. Aquaculture, 318 (1-2), pp. 54-60. https://doi.org/10.1016/j.aquaculture.2011.04.045
Article
Is there a direct role for erythrocytes in the immune response?
Morera D & MacKenzie S (2011) Is there a direct role for erythrocytes in the immune response?. Veterinary Research, 42 (1), Art. No.: 89. https://doi.org/10.1186/1297-9716-42-89
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Mauri I, Roher N, MacKenzie S, Romero A, Manchado M, Balasch JC, Bejar J, Alvarez MC & Tort L (2011) Molecular cloning and characterization of European seabass (Dicentrarchus labrax) and Gilthead seabream (Sparus aurata) complement component C3. Fish and Shellfish Immunology, 30 (6), pp. 1310-1322. https://doi.org/10.1016/j.fsi.2011.03.013
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Vraskou Y, Roher N, Diaz M, Antonescu CN, MacKenzie S & Planas JV (2011) Direct involvement of tumor necrosis factor-α in the regulation of glucose uptake in rainbow trout muscle cells. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 300 (3), pp. R716-R723. https://doi.org/10.1152/ajpregu.00514.2010
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Mauri I, Romero A, Acerete L, MacKenzie S, Roher N, Callol A, Cano I, Alvarez MC & Tort L (2011) Changes in complement responses in Gilthead seabream (Sparus aurata) and European seabass (Dicentrarchus labrax) under crowding stress, plus viral and bacterial challenges. Fish and Shellfish Immunology, 30 (1), pp. 182-188. https://doi.org/10.1016/j.fsi.2010.10.006
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Teles M, MacKenzie S, Boltana S, Callol A & Tort L (2011) Gene expression and TNF-alpha secretion profile in rainbow trout macrophages following exposures to copper and bacterial lipopolysaccharide. Fish and Shellfish Immunology, 30 (1), pp. 340-346. https://doi.org/10.1016/j.fsi.2010.11.006
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Boltana S, Reyes-Lopez F, Morera D, Goetz FW & MacKenzie S (2011) Divergent responses to peptidoglycans derived from different E. coli serotypes influence inflammatory outcome in trout, Oncorhynchus mykiss, macrophages. BMC Genomics, 12, Art. No.: 34. https://doi.org/10.1186/1471-2164-12-34
Article
Inflammation and innate immune response against viral infections in marine fish
Novoa B, MacKenzie S & Figueras A (2010) Inflammation and innate immune response against viral infections in marine fish. Current Pharmaceutical Design, 16 (38), pp. 4175-4184. https://doi.org/10.2174/138161210794519156
Article
Coping strategies in a strongly schooling fish, the common carp Cyprinus carpio
Huntingford FA, Andrew G, MacKenzie S, Morera D, Coyle SM, Pilarczyk M & Kadri S (2010) Coping strategies in a strongly schooling fish, the common carp Cyprinus carpio. Journal of Fish Biology, 76 (7), pp. 1576-1591. https://doi.org/10.1111/j.1095-8649.2010.02582.x
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MacKenzie S, Roher N, Boltana S & Goetz FW (2010) Peptidoglycan, not endotoxin, is the key mediator of cytokine gene expression induced in rainbow trout macrophages by crude LPS. Molecular Immunology, 47 (7-8), pp. 1450-1457. https://doi.org/10.1016/j.molimm.2010.02.009
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Crespo D, Bonnet E, Roher N, MacKenzie S, Krasnov A, Goetz FW, Bobe J & Planas JV (2010) Cellular and molecular evidence for a role of tumor necrosis factor alpha in the ovulatory mechanism of trout. Reproductive Biology and Endocrinology, 8, Art. No.: 34. https://doi.org/10.1186/1477-7827-8-34
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Goetz FW, Rosauer D, Sitar S, Goetz G, Simchick C, Roberts S, Johnson R, Murphy C, Bronte CR & MacKenzie S (2010) A genetic basis for the phenotypic differentiation between siscowet and lean lake trout (Salvelinus namaycush). Molecular Ecology, 19 (Supplement s1), pp. 176-196. https://doi.org/10.1111/j.1365-294X.2009.04481.x
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Donate C, Balasch JC, Callol A, Bobe J, Tort L & MacKenzie S (2010) The effects of immunostimulation through dietary manipulation in the rainbow Trout; Evaluation of mucosal immunity. Marine Biotechnology, 12 (1), pp. 88-99. https://doi.org/10.1007/s10126-009-9203-4
Article
Endotoxin recognition in fish results in inflammatory cytokine secretion not gene expression
Roher N, Callol A, Planas JV, Goetz FW & MacKenzie S (2010) Endotoxin recognition in fish results in inflammatory cytokine secretion not gene expression. Innate Immunity, 17 (1), pp. 16-28. https://doi.org/10.1177/1753425909348232
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Castillo J, Teles M, MacKenzie S & Tort L (2009) Stress-related hormones modulate cytokine expression in the head kidney of gilthead seabream (Sparus aurata). Fish and Shellfish Immunology, 27 (3), pp. 493-499. https://doi.org/10.1016/j.fsi.2009.06.021
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Boltana S, Donate C, Goetz FW, MacKenzie S & Balasch JC (2009) Characterization and expression of NADPH oxidase in LPS-, poly(I:C)- and zymosan-stimulated trout (Oncorhynchus mykiss W.) macrophages. Fish and Shellfish Immunology, 26 (4), pp. 651-661. https://doi.org/10.1016/j.fsi.2008.11.011
Article
Screening for coping style increases the power of gene expression studies
MacKenzie S, Ribas L, Pilarczyk M, Capdevila DM, Kadri S & Huntingford FA (2009) Screening for coping style increases the power of gene expression studies. PLoS ONE, 4 (4), Art. No.: e5314. https://doi.org/10.1371/journal.pone.0005314
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Functional genomics with microarrays in fish biology and fisheries
Goetz FW & MacKenzie S (2008) Functional genomics with microarrays in fish biology and fisheries. Fish and Fisheries, 9 (4), pp. 378-395. https://doi.org/10.1111/j.1467-2979.2008.00301.x
Article
Genomic tools for examining immune gene function in salmonid fish
Martin SAM, Collet B, MacKenzie S, Evensen O & Secombes CJ (2008) Genomic tools for examining immune gene function in salmonid fish. Reviews in Fisheries Science, 16 (Supplement 1), pp. 112-118. https://doi.org/10.1080/10641260802325476
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Bonnet E, Crespo D, Roher N, MacKenzie S, Goetz FW, Bobe J & Planas JV (2008) Reproductive consequences of an immune challenge during the preovulatory period in trout: Possible mediatory role of tumor necrosis factor α. Cybium, 32 (2 Supplement), pp. 148-150. http://sfi.mnhn.fr/cybium/numeros/2008/322%20suppl%20ISRPF/06-Gametogenesis%20and%20gamete%20biology/63-Planas%20O48.pdf
Article
Roher N, Samokhvalov V, Diaz M, MacKenzie S, Klip A & Planas JV (2008) The proinflammatory cytokine tumor necrosis factor-α increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6. Endocrinology, 149 (4), pp. 1880-1889. https://doi.org/10.1210/en.2007-1045
Article
Molecular characterization of interleukin-6 in the gilthead seabream (Sparus aurata)
Castellana B, Iliev DB, Sepulcre MP, MacKenzie S, Goetz FW, Mulero V & Planas JV (2008) Molecular characterization of interleukin-6 in the gilthead seabream (Sparus aurata). Molecular Immunology, 45 (12), pp. 3363-3370. https://doi.org/10.1016/j.molimm.2008.04.012
Article
Characterization of rainbow trout IL-6 and possible relationship with reproductive function
Goetz FW, Bobe J, Iliev DB, Planas JV, Castellana B & MacKenzie S (2008) Characterization of rainbow trout IL-6 and possible relationship with reproductive function. Cybium, 32 (2 supplement), p. 263. http://sfi.mnhn.fr/cybium/numeros/2008/322%20suppl%20ISRPF/06-Gametogenesis%20and%20gamete%20biology/136-Goetz%20P183.pdf
Article
MacKenzie S, Balasch JC, Novoa B, Ribas L, Roher N, Krasnov A & Figueras A (2008) Comparative analysis of the acute response of the trout, O. mykiss, head kidney to in vivo challenge with virulent and attenuated infectious hematopoietic necrosis virus and LPS-induced inflammation. BMC Genomics, 9, Art. No.: 141. https://doi.org/10.1186/1471-2164-9-141
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Castillo J, Castellana B, Acerete L, Planas JV, Goetz FW, MacKenzie S & Tort L (2008) Stress-induced regulation of steroidogenic acute regulatory protein expression in head kidney of Gilthead seabream (Sparus aurata). Journal of Endocrinology, 196 (2), pp. 313-322. https://doi.org/10.1677/JOE-07-0440
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Ribas L, Roher N, Martinez M, Balasch JC, Donate C, Goetz FW, Iliev DB, Planas JV, Tort L & MacKenzie S (2008) Characterization and expression of the transcription factor PU.1 during LPS-induced inflammation in the rainbow trout (Oncorhynchus mykiss). Fish and Shellfish Immunology, 24 (1), pp. 35-45. https://doi.org/10.1016/j.fsi.2007.07.009
Article
CD83 expression in sea bream macrophages is a marker for the LPS-induced inflammatory response
Donate C, Roher N, Balasch JC, Ribas L, Goetz FW, Planas JV, Tort L & MacKenzie S (2007) CD83 expression in sea bream macrophages is a marker for the LPS-induced inflammatory response. Fish and Shellfish Immunology, 23 (4), pp. 877-885. https://doi.org/10.1016/j.fsi.2007.03.016
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Acerete L, Balasch JC, Castellana B, Redruello B, Roher N, Canario AVM, Planas JV, MacKenzie S & Tort L (2007) Cloning of the glucocorticoid receptor (GR) in gilthead seabream (Sparus aurata). Differential expression of GR and immune genes in gilthead seabream after an immune challenge. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 148 (1), pp. 32-43. https://doi.org/10.1016/j.cbpb.2007.04.015
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Cooper CA, Shayeghi M, Techau ME, Capdevila DM, MacKenzie S, Durrant CJ & Bury NR (2007) Analysis of the rainbow trout solute carrier 11 family reveals iron import ≤ pH 7.4 and a functional isoform lacking transmembrane domains 11 and 12. FEBS Letters, 581 (14), pp. 2599-2604. https://doi.org/10.1016/j.febslet.2007.04.081
