Senior Lecturer
Institute of Aquaculture Pathfoot Building, University of Stirling, Stirling, FK9 4LA
In my PhD thesis, carried out at the UFZ centre for Environmental Research in Leipzig, Germany, I have studied different biochemical biomarkers of pollution in fish and fish cell cultures. Before joining the Institute of Aquaculture in September 2006, I have worked as postdoctoral researcher in France (Joint Research Unit for Fish Physiology, Biodiversity and the Environment SCRIBE, Institute National de la Recherche Agronomique, Rennes) and the UK (King’s College London).
My current research focuses on unravelling the molecular pathways by which chemotherapeutants unfold their action in sea lice. Identifying the molecular determinants of the susceptibility of sea lice to veterinary drugs will contribute to improving the control of these and other fish parasites in aquaculture. Further research interests of mine include firstly the assessment of potential adverse effects of fish medicines on non-target marine biota, and secondly the elucidation of roles of biochemical factors within the host fish for the efficiency of drug uptake and action.
Enhancing Diversity to Overcome Resistance Evolution
PI: Professor Matthew Tinsley
Funded by: Biotechnology and Biological Sciences Research Council
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Pulcea KTP
PI: Professor James Bron
Funded by: Innovate UK and Pulcea
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Preliminary safety study of an aquaculture disinfectant when used against sea lice
PI:
Funded by: Ecolab
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Identifying molecular determinants of drug susceptibility in salmon lice (Lepeophtheirus salmonis)
PI:
Funded by: Biotechnology and Biological Sciences Research Council
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Identifying molecular determinants of drug susceptibility in salmon lice (Lepeophtheirus salmonis)
PI: Dr Armin Sturm
Funded by: Salmon Scotland
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Book Chapter
Evolution of sea louse (Copepoda: Caligidae) resistance against control agents
Sturm A, Tschesche C & Bron J (2022) Evolution of sea louse (Copepoda: Caligidae) resistance against control agents. In: Treasurer J, Bricknell I & Bron J (eds.) Sea Lice Biology and Control. Great Easton, UK: 5M Books, pp. 294-325. https://5mbooks.com/product/sea-lice-biology-and-control
Article
Tschesche C, Bekaert M, Bassett DI, Boyd S, Bron JE & Sturm A (2022) Key role of mitochondrial mutation Leu107Ser (COX1) in deltamethrin resistance in salmon lice (Lepeophtheirus salmonis). Scientific Reports, 12 (1), Art. No.: 10356. https://doi.org/10.1038/s41598-022-14023-1
Article
Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis)
Tschesche C, Bekaert M, Humble JL, Bron JE & Sturm A (2021) Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis). Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 248, Art. No.: 109095. https://doi.org/10.1016/j.cbpc.2021.109095
Article
Tschesche C, Bekaert M, Bassett DI, Mitchell C, North B, Boyd S, Carmona‐Antoñanzas G, Bron JE & Sturm A (2021) Investigation of deltamethrin resistance in salmon lice (Lepeophtheirus salmonis) provides no evidence for roles of mutations in voltage-gated sodium channels. Pest Management Science, 77 (2), pp. 1052-1060. https://doi.org/10.1002/ps.6120
Article
Humble JL, Carmona-Antoñanzas G, McNair CM, Nelson DR, Bassett DI, Egholm I, Bron JE, Bekaert M & Sturm A (2019) Genome-wide survey of cytochrome P450 genes in the salmon louse Lepeophtheirus salmonis (Krøyer, 1837). Parasites and Vectors, 12 (1), Art. No.: 563. https://doi.org/10.1186/s13071-019-3808-x
Article
Carmona-Antoñanzas G, Helgesen KO, Humble JL, Tschesche C, Bakke MJ, Gamble L, Bekaert M, Bassett DI, Horsberg TE, Bron JE & Sturm A (2019) Mutations in voltage-gated sodium channels from pyrethroid resistant salmon lice (Lepeophtheirus salmonis). Pest Management Science, 75 (2), pp. 527-536. https://doi.org/10.1002/ps.5151
Article
Jacobs A, De Noia M, Praebel K, Kanstad-Hanssen O, Paterno M, Jackson D, McGinnity P, McGinnity P, Sturm A, Elmer KR & Llewellyn MS (2018) Genetic fingerprinting of salmon louse (Lepeophtheirus salmonis) populations in the North-East Atlantic using a random forest classification approach. Scientific Reports, 8 (1), Art. No.: 1203. https://doi.org/10.1038/s41598-018-19323-z
Article
Carmona-Antoñanzas G, Bekaert M, Humble JL, Boyd S, Roy W, Bassett DI, Houston RD, Gharbi K, Bron JE & Sturm A (2017) Maternal inheritance of deltamethrin resistance in the salmon louse Lepeophtheirus salmonis (Krøyer) is associated with unique mtDNA haplotypes. PLoS ONE, 12 (7), Art. No.: e0180625. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180625; https://doi.org/10.1371/journal.pone.0180625
Article
Time-to-response toxicity analysis as a method for drug susceptibility assessment in salmon lice
Carmona-Antoñanzas G, Humble JL, Carmichael SN, Heumann J, Christie HRL, Green DM, Bassett DI, Bron JE & Sturm A (2016) Time-to-response toxicity analysis as a method for drug susceptibility assessment in salmon lice. Aquaculture, 464, pp. 570-575. https://doi.org/10.1016/j.aquaculture.2016.08.007
Article
Mixture toxicity effects of sea louse control agents in Daphnia magna
Rose S, Altenburger R & Sturm A (2016) Mixture toxicity effects of sea louse control agents in Daphnia magna. Chemosphere, 144, pp. 599-606. https://doi.org/10.1016/j.chemosphere.2015.08.053
Article
Carmona-Antonanzas G, Carmichael SN, Heumann J, Taggart J, Bron J, Bekaert M, Sturm A & Gharbi K (2015) A survey of the ATP-binding cassette (ABC) gene superfamily in the salmon louse (Lepeophtheirus salmonis). PLoS ONE, 10 (9), Art. No.: e0137394. https://doi.org/10.1371/journal.pone.0137394
Article
Transcriptomic insights on the ABC transporter gene family in the salmon louse Caligus rogercresseyi
Valenzuela-Munoz V, Sturm A & Gallardo-Escarate C (2015) Transcriptomic insights on the ABC transporter gene family in the salmon louse Caligus rogercresseyi. Parasites and Vectors, 8, Art. No.: 209. https://doi.org/10.1186/s13071-015-0801-x
Article
Current advances on ABC drug transporters in fish
Luckenbach T, Fischer S & Sturm A (2014) Current advances on ABC drug transporters in fish. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 165, pp. 28-52. https://doi.org/10.1016/j.cbpc.2014.05.002
Poster
Drug susceptibility assessment of sea lice by time-to-response toxicity analysis
Carmichael SN, Christie HRL, Heumann J, Bassett DI, Bron J & Sturm A (2014) Drug susceptibility assessment of sea lice by time-to-response toxicity analysis. 10th International Sea Lice Conference, Portland, ME, USA, 31.08.2014-05.09.2014. http://sealice2014.businesscatalyst.com/assets/abstract-book-v6.2-final2.pdf
Article
Heumann J, Carmichael SN, Bron J & Sturm A (2014) Isolation and characterisation of four partial cDNA sequences encoding multidrug resistance-associated proteins (MRPs) in the salmon louse Lepeophtheirus salmonis (Krøyer, 1837). Aquaculture, 424-425, pp. 207-214. https://doi.org/10.1016/j.aquaculture.2013.12.015
Article
Carmichael SN, Bekaert M, Taggart J, Christie HRL, Bassett DI, Bron J, Skuce P, Gharbi K, Skern-Mauritzen R & Sturm A (2013) Identification of a sex-linked SNP marker in the salmon louse (Lepeophtheirus salmonis) using RAD sequencing. PLoS ONE, 8 (10), Art. No.: e77832. https://doi.org/10.1371/journal.pone.0077832
Article
Carmichael SN, Bron J, Taggart J, Ireland J, Bekaert M, Burgess S, Skuce P, Nisbet A, Gharbi K & Sturm A (2013) Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expression. BMC Genomics, 14, Art. No.: 408. https://doi.org/10.1186/1471-2164-14-408
Article
Evidence for a divergence in function between two glucocorticoid receptors from a basal teleost
Li Y, Sturm A, Cunningham P & Bury NR (2012) Evidence for a divergence in function between two glucocorticoid receptors from a basal teleost. BMC Evolutionary Biology, 12 (1), Art. No.: 137. https://doi.org/10.1186/1471-2148-12-137
Article
Heumann J, Carmichael SN, Bron J, Tildesley A & Sturm A (2012) Molecular cloning and characterisation of a novel P-glycoprotein in the salmon louse Lepeophtheirus salmonis. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 155 (2), pp. 198-205. https://doi.org/10.1016/j.cbpc.2011.08.004
Article
Kiilerich P, Milla S, Sturm A, Valotaire C, Chevolleau S, Giton F, Terrien X, Fiet J, Fostier A, Debrauwer L & Prunet P (2011) Implication of the mineralocorticoid axis in rainbow trout osmoregulation during salinity acclimation. Journal of Endocrinology, 209 (2), pp. 221-235. https://doi.org/10.1530/JOE-10-0371
Article
Molecular determinants of hormone sensitivity in rainbow trout glucocorticoid receptors 1 and 2
Sturm A, Colliar L, Leaver M & Bury NR (2011) Molecular determinants of hormone sensitivity in rainbow trout glucocorticoid receptors 1 and 2. Molecular and Cellular Endocrinology, 333 (2), pp. 181-189. http://www.sciencedirect.com/science/article/pii/S0303720711000025; https://doi.org/10.1016/j.mce.2010.12.033
Article
Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β
Colliar L, Sturm A & Leaver M (2011) Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor α and β. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 153 (1), pp. 168-173. https://doi.org/10.1016/j.cbpc.2010.10.008
Article
Mapping of AF1 transactivation domains in duplicated rainbow trout glucocorticoid receptors
Sturm A, Bron J, Green D & Bury NR (2010) Mapping of AF1 transactivation domains in duplicated rainbow trout glucocorticoid receptors. Journal of Molecular Endocrinology, 45 (6), pp. 391-404. https://doi.org/10.1677/JME-09-0152
Article
Becker H, Sturm A, Bron J, Schirmer K & Bury NR (2009) The A/B Domain of the Teleost Glucocorticoid Receptors Influences Partial Nuclear Localization in the Absence of Hormone. Endocrinology, 149 (9), pp. 4567-4576. https://doi.org/10.1210/en.2007-1683
Conference Abstract
Colliar L, Leaver M & Sturm A (2009) A reporter gene assay to test for pollutant activation of fish peroxisome proliferator-activated receptors. Annual Main Meeting of the Society of Experimental Biology 2009, Glasgow, 28/06/2009 - 01/07/2009. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 153 (2, Supplement), pp. S88-S89. https://doi.org/10.1016/j.cbpa.2009.04.084
Article
The ABC transporter gene family of Daphnia pulex
Sturm A, Cunningham P & Dean M (2009) The ABC transporter gene family of Daphnia pulex. BMC Genomics, 10 (1), p. 170. http://www.biomedcentral.com/1471-2164/10/170; https://doi.org/10.1186/1471-2164-10-170
Article
Stress and innate immunity in carp: Corticosteroid receptors and pro-inflammatory cytokines
Stolte EH, Nabuurs SB, Bury NR, Sturm A, Flik G, Savelkoul HFJ & Verburg-van Kemenade BML (2008) Stress and innate immunity in carp: Corticosteroid receptors and pro-inflammatory cytokines. Molecular Immunology, 46 (1), pp. 70-79. https://doi.org/10.1016/j.molimm.2008.07.022
Article
Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio
Stolte EH, de Mazon AF, Leon-Koosterziel KM, Jesiak M, Bury NR, Sturm A, Savelkoul HFJ, Verburg-van Kemenade BML & Flik G (2008) Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio. Journal of Endocrinology, 198 (2), pp. 403-417. https://doi.org/10.1677/JOE-08-0100
Article
Milla S, Terrien X, Sturm A, Ibrahim F, Giton F, Fiet J, Prunet P & Le Gac F (2008) Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity?. Reproductive Biology and Endocrinology, 6 (1). http://www.rbej.com/content/6/1/19; https://doi.org/10.1186/1477-7827-6-19
Article
Bury NR, Chung MJ, Sturm A, Walker PA & Hogstrand C (2008) Cortisol stimulates the zinc signaling pathway and expression of metallothioneins and ZnT1 in rainbow trout gill epithelial cells. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 294 (2), pp. R623-R629. http://ajpregu.physiology.org/; https://doi.org/10.1152/ajpregu.00646.2007
Article
Evolution of the corticosteroid receptor signalling pathway in fish
Bury NR & Sturm A (2007) Evolution of the corticosteroid receptor signalling pathway in fish. General and Comparative Endocrinology, 153 (1-3), pp. 47-56. https://doi.org/10.1016/j.ygcen.2007.03.009
Article
Sturm A, Radau TS, Hahn T & Schulz R (2007) Inhibition of rainbow trout acetylcholinesterase by aqueous and suspended particle-associated organophosphorous insecticides. Chemosphere, 68 (4), pp. 605-612. http://www.sciencedirect.com/science/journal/00456535; https://doi.org/10.1016/j.chemosphere.2007.02.056
Article
Multiple corticosteroid receptors in fish: From old ideas to new concepts
Prunet P, Sturm A & Milla S (2006) Multiple corticosteroid receptors in fish: From old ideas to new concepts. General and Comparative Endocrinology, 147 (1), pp. 17-23. https://doi.org/10.1016/j.ygcen.2006.01.015
Book Chapter
P-glycoproteins and xenobiotic efflux transport in fish
Sturm A & Segner H (2005) P-glycoproteins and xenobiotic efflux transport in fish. In: Mommsen T & Moon T (eds.) Environmental Toxicology. Biochemistry and Molecular Biology of Fishes, Volume 6. Amsterdam: Elsevier, pp. 495-533. http://www.sciencedirect.com/science/article/pii/S1873014005800219
Article
Sturm A, Bury NR, Dengreville L, Fagart J, Flouriot G, Rafestin-Oblin ME & Prunet P (2005) 11-Deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology, 146 (1), pp. 47-55. https://doi.org/10.1210/en.2004-0128
Article
Evidence for two distinct functional glucocorticoid receptors in teleost fish
Bury NR, Sturm A, Le Rouzic P, Lethimonier C, Ducouret B, Guiguen Y, Robinson-Rechavi M, Laudet V, Rafestin-Oblin ME & Prunet P (2003) Evidence for two distinct functional glucocorticoid receptors in teleost fish. Journal of Molecular Endocrinology, 31 (1), pp. 141-156. https://doi.org/10.1677/jme.0.0310141
Article
Sturm A, Ziemann C, Hirsch-Ernst KI & Segner H (2001) Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 281 (4), pp. R1119-R1126. http://ajpregu.physiology.org/content/281/4/R1119.short
Article
Sturm A, Cravedi J, Perdu E & Segner H (2001) Effects of prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: A comparative in vitro/in vivo-assessment using cultured hepatocytes. Aquatic Toxicology, 53 (3-4), pp. 229-245. https://doi.org/10.1016/S0166-445X%2801%2900168-0
Article
Sturm A, Cravedi J & Segner H (2001) Prochloraz and nonylphenol diethoxylate inhibit an mdr1-like activity in vitro, but do not alter hepatic levels of P-glycoprotein in trout exposed in vivo. Aquatic Toxicology, 53 (3-4), pp. 215-228. https://doi.org/10.1016/S0166-445X%2801%2900167-9
Article
Smith RW, Blaney SC, Dowling K, Sturm A, Jonsson M & Houlihan DF (2001) Protein synthesis costs could account for the tissue-specific effects of sub-lethal copper on protein synthesis in rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology, 53 (3-4), pp. 265-277. https://doi.org/10.1016/S0166-445X%2801%2900171-0
Article
Wogram J, Sturm A, Segner H & Liess M (2001) Effects of parathion on acetylcholinesterase, butyrylcholinesterase, and carboxylesterase in three-spined stickleback (Gasterosteus aculeatus) following short-term exposure. Environmental Toxicology and Chemistry, 20 (7), pp. 1528-1531. https://doi.org/10.1002/etc.5620200716
Article
Sturm A, Wogram J, Segner H & Liess M (2000) Different sensitivity to organophosphates of acetylcholinesterase and butyrylcholinesterase from three-spined stickleback (Gasterosteus aculeatus): Application in biomonitoring. Environmental Toxicology and Chemistry, 19 (6), pp. 1607-1615. https://doi.org/10.1002/etc.5620190618
Article
Sturm A, da Silva de Assis HC & Hansen P (1999) Cholinesterases of marine teleost fish: Enzymological characterization and potential use in the monitoring of neurotoxic contamination. Marine Environmental Research, 47 (4), pp. 389-398. https://doi.org/10.1016/S0141-1136%2898%2900127-5
Article
Sturm A, Wogram J, Hansen P & Liess M (1999) Potential use of cholinesterase in monitoring low levels of organophosphates in small streams: Natural variability in three-spined stickleback (Gasterosteus aculeatus) and relation to pollution. Environmental Toxicology and Chemistry, 18 (2), pp. 194-200. https://doi.org/10.1002/etc.5620180214
Article
Sturm A & Hansen P (1999) Altered cholinesterase and monooxygenase levels in Daphnia magna and Chironomus riparius exposed to environmental pollutants. Ecotoxicology and Environmental Safety, 42 (1), pp. 9-15. https://doi.org/10.1006/eesa.1998.1721
