Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo

Citation

Cahusac P & Wan H (2007) Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo. Neuroscience, 146 (1), pp. 202-212. https://doi.org/10.1016/j.neuroscience.2007.01.049

Abstract
Group II metabotropic (mGlu) receptors are known to play an important role in regulating the release of excitatory transmitter in a number of brain areas. Previous experiments demonstrated that (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) depressed excitatory transmission in the adult rat barrel cortex. Here we show, using in vivo extracellular single unit recordings and iontophoretic application of drugs, that selective activation of Group II mGlu receptors depresses excitatory but not inhibitory transmission. The selective Group II receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) had similar depressant effects to 1S,3R-ACPD on tactile evoked responses of rapidly adapting neurons. The depressant effects were seen on shorter latency (

Keywords
Adult; ADULT-RAT; AREAS; Brain; CORTEX; Depression; DRUGS; experiment; EXPERIMENTS; glutamate; glutamate receptor; GLUTAMATE RECEPTORS; in vivo; IN-VIVO; INHIBITION; involvement; LIMITS; location; NUMBER; PLASTICITY; Play; rat; RECEPTOR; RECEPTORS; RELEASE; responses; Role; SINGLE; support; TRANSMISSION

Journal
Neuroscience: Volume 146, Issue 1