How Bursts Shape the STDP Curve in the Presence/Absence of GABAergic Inhibition

Citation

Cutsuridis V, Cobb SR & Graham B (2009) How Bursts Shape the STDP Curve in the Presence/Absence of GABAergic Inhibition. In: Alippi C, Polycarpou M, Panayioutou C & Ellinas G (eds.) Artificial Neural Networks – ICANN 2009: 19th International Conference, Limassol, Cyprus, September 14-17, 2009, Proceedings, Part I. Lecture Notes in Computer Science, 5768. ICANN 2009: 19th International Conference on Artificial Neural Networks: An Annual Conference of the European Neural Network Society, Limassol, Cyprus, 14.09.2009-17.09.2009. Berlin Heidelberg: Springer, pp. 229-238. http://link.springer.com/chapter/10.1007%2F978-3-642-04274-4_24; https://doi.org/10.1007/978-3-642-04274-4_24

Abstract
It has been known for some time that the synapses of the CA1 pyramidal cells are surprisingly unreliable at signalling the arrival of single spikes to the postsynaptic neuron. On the other hand, bursts of spikes are reliably signalled, because transmitter release is facilitated. In the hippocampus, a single burst can produce long-term synaptic modifications. Bursts of spikes in addition to increasing reliability of synaptic transmission, they have been shown to provide effective mechanisms for selective communication between neurons in a network.We investigate via computer simulations how the profile of spike-timing-dependent plasticity (STDP) in the CA1 pyramidal cell synapses is affected when an excitatory burst of spikes applied to dendrites is paired with an excitatory single spike applied to the soma in the absence and presence of a 100Hz GABAergic inhibitory spike train applied to the dendrites. We report that the shape of the STDP curve strongly depends on the burst interspike interval in the presence/absence of GABAA when a presynaptic burst and a postsynaptic spike are paired together.

Keywords
Hippocampus; CA1 pyramidal neuron; Computer model; STDP; GABA; LTP; LTD; Calcium