Unilateral voluntary hand movement and regional cerebral uptake of technetium-99m-exametazime in human control subjects

Citation

Ebmeier KP, Murray C, Dougall N, O'Carroll R & Goodwin GM (1992) Unilateral voluntary hand movement and regional cerebral uptake of technetium-99m-exametazime in human control subjects. Journal of Nuclear Medicine, 33 (9), pp. 1623-1627. http://jnm.snmjournals.org/content/33/9/1623.full.pdf+html

Abstract
The study examines the sensitivity of a region of interest approach to detect functional changes in brain metabolism with SPECT and split-dose 99mTc-exametazime by replicating a simple hand movement experiment previously carried out with PET. Regional uptake of 99mTc-exametazime was determined in 12 healthy controls before and during a thumb-digit opposition task. Analysis of regional uptake was carried out blind to the hand used in the opposition task and showed a significant unilateral activation effect in a pericentral region of interest with opposite results in left- and right-handed activation. The maximum contralateral increase in tracer uptake was 16% before and 26% after correction for back diffusion. This is in good agreement with previous results employing absolute cerebral blood flow determination with PET and confirms the usefulness of 99mTc-exametazime SPECT for the examination of functional metabolic changes.

Journal
Journal of Nuclear Medicine: Volume 33, Issue 9