Principles of Computational Modelling in Neuroscience

Citation

Sterratt DC, Graham B, Gillies A & Willshaw DJ (2011) Principles of Computational Modelling in Neuroscience. Cambridge: Cambridge University Press. http://www.cambridge.org/us/academic/subjects/life-sciences/neuroscience/principles-computational-modelling-neuroscience

Abstract
The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signaling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modeling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience. - Presents models in the context of the underlying biology and biophysics, enabling readers to engage with and understand their relevance - Complex mathematical details are highlighted and explained in boxes alongside the main text, so that readers can follow the discussion easily and clearly - Associated website (www.compneuroprinciples.org) provides sample codes and up-to-date links to external resources, such as simulators and databases.