Diagnosing dengue virus infection: rapid tests and the role of micro/nanotechnologies

Citation

Zhang B, Salieb-Beugelaar GB, Nigo MM, Weidmann M & Hunziker P (2015) Diagnosing dengue virus infection: rapid tests and the role of micro/nanotechnologies. Nanomedicine: Nanotechnology, Biology and Medicine, 11 (7), pp. 1745-1761. https://doi.org/10.1016/j.nano.2015.05.009

Abstract
Due to the progressive spread of the dengue virus and a rising incidence of dengue disease, its rapid diagnosis is important for developing countries and of increasing relevance for countries in temperate climates. Recent advances in bioelectronics, micro- and nanofabrication technologies have led to new miniaturized point-of-care devices and analytical platforms suited for rapid detection of infections. Starting from the available tests for dengue diagnosis, this review examines emerging rapid, micro/nanotechnologies-based tools, including label-free biosensor methods, microarray and microfluidics platforms, which hold significant potential, but still need further development and evaluation. The epidemiological and clinical setting as key determinants for selecting the best analytical strategy in patients presenting with fever is then discussed. This review is aimed at the clinicians and microbiologists to deepen understanding and enhance application of dengue diagnostics, and also serves as knowledge base for researchers and test developers to overcome the challenges posed by this disease.

Keywords
Dengue virus; Rapid diagnosis; Point-of-care; Label-free biosensor; Microfluidic platform

Journal
Nanomedicine: Nanotechnology, Biology and Medicine: Volume 11, Issue 7