Mathematical Analysis of a Clonal Evolution Model of Tumour Cell Proliferation

Citation

Farkas JZ & Webb GF (2017) Mathematical Analysis of a Clonal Evolution Model of Tumour Cell Proliferation. Journal of Evolution Equations, 17 (1), pp. 275-308. https://doi.org/10.1007/s00028-016-0369-8

Abstract
We investigate a partial differential equation model of a cancer cell population, which is structured with respect to age and telomere length of cells. We assume a continuous telomere length structure, which is applicable to the clonal evolution model of cancer cell growth. This model has a non-standard non-local boundary condition. We establish global existence of solutions and study their qualitative behaviour. We study the effect of telomere restoration on cancer cell dynamics. Our results indicate that without telomere restoration, the cell population extinguishes. With telomere restoration, exponential growth occurs in the linear model. We further characterise the specific growth behaviour of the cell population for special cases. We also study the effects of crowding induced mortality on the qualitative behaviour, and the existence and stability of steady states of a nonlinear model incorporating crowding effect. We present examples and extensive numerical simulations, which illustrate the rich dynamic behaviour of the linear and nonlinear models.

Keywords
Cancer modelling; structured populations; semigroups of operators; asymptotic behaviour; telomere self-renewal

Journal
Journal of Evolution Equations: Volume 17, Issue 1