Article
Details
Citation
Laird BJ, McMillan D, Skipworth RJE, Fallon MT, Paval DR, McNeish I & Gallagher IJ (2021) The Emerging Role of Interleukin 1β (IL-1β) in Cancer Cachexia. Inflammation, 44 (4), pp. 1223-1228. https://doi.org/10.1007/s10753-021-01429-8
Abstract
Treatment of cancer cachexia remains an unmet need. The host-tumour interface and the resulting sequestration of the pro-inflammatory cytokine Il-1β is critical in cachexia development. Neuroinflammation mediated via IL-1β through the hypothalamic pituitary axis results in increased muscle proteolysis and adipose lipolysis, thus creating a prolonged stress-like environment with loss of appetite and increased resting energy expenditure. Recent trials using a monoclonal antibody targeting IL-1β, canakinumab, have shown a potential role in lung cancer; however, a potential role of targeting IL-1β to treat cachexia in patients with lung cancer is unclear, yet the underlying pathophysiology provides a sound rationale that this may be a viable therapeutic approach.
Keywords
Inflammation; Cachexia; Interleukin-1 beta
Journal
Inflammation: Volume 44, Issue 4
Status | Published |
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Publication date | 31/08/2021 |
Publication date online | 27/04/2021 |
Date accepted by journal | 27/01/2021 |
URL | http://hdl.handle.net/1893/32629 |
ISSN | 0360-3997 |
eISSN | 1573-2576 |
People (1)
PhD Researcher, Sport