Emotional lability in focal hippocampal damage

Citation

Argyropoulos G, Moore L, Loane C, Roca-Fernandez A, Lage-Martinez C & Butler CR (2019) Emotional lability in focal hippocampal damage. BNA Festival of Neuroscience 2019, Dublin, 14.04.2019-17.04.2019. https://doi.org/10.1177/2398212819855490

Abstract
Introduction: Basic research on animal models has established that the primate anterior hippocampus (ventral hippocampus in rodents) is embedded within networks regulating emotion and affect. Nevertheless, very little is known about emotional dysregulation in patients with hippocampal damage. We thus aimed to assess the negative emotional sequelae in focal hippocampal atrophy following autoimmune limbic encephalitis, a neurological disease typically associated with hippocampal damage and residual cognitive and emotional impairment. We focused on emotional lability and hypothesized that it would be associated with abnormalities in emotional networks involving the anterior HPC, the broader HPC-diencephalic-cingulate networks, the AMG, and cortico-ponto-cerebellar circuits.