Obesity in Kidney Transplantation

Citation

Chan W, Bosch JA, Jones D, McTernan PG, Phillips AC & Borrows R (2014) Obesity in Kidney Transplantation. Journal of Renal Nutrition, 24 (1), pp. 1-12. https://doi.org/10.1053/j.jrn.2013.09.002

Abstract
Kidney transplantation is the preferred modality of renal replacement therapy. Long-term patient and graft survival have only improved marginally over the recent decade, mainly because of the development of cardiovascular disease after transplantation. Obesity is a risk factor for cardiovascular disease and is common before and after transplantation. This article reviews the literature assessing the role of pre- and post-transplant obesity on patient and graft survival, discusses the underlying obesity-related mechanisms leading to inferior kidney transplant outcomes, and explores the role of nutritional intervention on improving long-term outcomes of transplantation. Although the role of pretransplant obesity remains uncertain, post-transplant obesity increases the risk of graft failure and mortality. Nutritional intervention is effective in achieving post-transplant weight loss, but the effect on long-term outcomes has not been established. Future research should focus on conducting nutritional intervention studies aiming to improve long-term outcomes of kidney transplantation.

Keywords
Obesity; Inflammation; Sarcopenia; Kidney; Transplant

Journal
Journal of Renal Nutrition: Volume 24, Issue 1

• Obesity In Kidney Transplantation Postprint